Protein Modification Reagents
eMolecules 932741-19-0 | Propargyl-PeG3-amine | MFCD20720810 | 1g
Ambeed | Propargyl-PeG3-amine | 1g | 602850701 | A755212 | 932741-19-0 | MFCD20720810 | 187.239 | C9H17NO3
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Medchemexpress LLC Tos-PEG4-acid | 1453117-42-4 | 97.2% | 250 MG
Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables PROTACs to contain two different ligands connected by a linker
- Facilitates targeting of E3 ubiquitin ligase and target proteins
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-acid) | 2110449-00-6 | 96.7% | C33H40N2O10 | 50 MG
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It also functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs are composed of two different ligands connected by a linker, enabling selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent with a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Plga-peg-mal (60kda-3.4kda, la:ga ratio 75:25) | 95.0% | 60kDA-3.4kDA | 50 MG
PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) is a poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticle. It has a molecular weight range of 60kDA to 3.4kDA and a 75:25 lactic acid (LA) to glycolic acid (GA) ratio. This product is for research use only.
- Type: poly(lactide-co-glycolide)-block-poly(ethylene glycol) nanoparticles
- Molecular weight: 60kDA to 3.4kDA
- Lactic acid to glycolic acid ratio: 75:25
- Purity: 95.0%
- Appearance: solid
- Color: white to off-white
- Storage: powder at -20°C for 3 years or 4°C for 2 years; in solvent at -80°C for 6 months or -20°C for 1 month
- Solubility in DMSO: 100 mg/mL
Cayman Chemical BIOnT PROTAC Fragmnt lbrar 1mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
![eMolecules 721431-18-1 | 3-Amino(peg4)propionic acid biotinamide | Combi-Blocks | MFCD08457831 | 491.600 | C21H37N3O8S | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 335350416](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1767738.jpg-250.jpg)
eMolecules 721431-18-1 | 3-Amino(peg4)propionic acid biotinamide | Combi-Blocks | MFCD08457831 | 491.600 | C21H37N3O8S | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 335350416
3-Amino(peg4)propionic acid biotinamide | Combi-Blocks | 721431-18-1 | MFCD08457831 | 491.600 | C21H37N3O8S | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 1g | 335350416
Vector Laboratories SY-9 DBCO (FP-1709) 5mg
SY-9 (QSY®-9 equivalent) is a more hydrophilic version of the popular SY-7 dark quencher (QSY®-7 equivalent). This nonfluorescent acceptor dye is often used for the preparation of peptide FRET probes. A broad and intense quenching range from 500-600 nm makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with dyes emitting at 500 nm to 600 nm, such as Fluorescein, Oregon Green, Carboxyrhodamine 110 (Rhodamine Green), Alexa Fluor® 488, 532, 546, 555, 568, Cy3, TAMRA and ROX dyes.SY-9 DBCO reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
Medchemexpress LLC Bis-PEG4-NHS ester | 1314378-11-4 | MFCD20228963 | 97.0% | 488.44 | C20H28N2O12 | 250 MG
Bis-PEG4-NHS ester is a noncleavable four-unit polyethylene glycol (PEG) linker bearing N-hydroxysuccinimide (NHS) ester reactive groups used for antibody-agent conjugation (ADC) and general bioconjugation applications. It is supplied for research use and is available in multiple pack sizes.
- Noncleavable 4-unit PEG linker.
- Terminal NHS ester groups for coupling to primary amines.
- High reported purity (97.0%).
- Molecular weight 488.44 and formula C20H28N2O12.
- Available in small to large pack sizes, including 250 MG.
Medchemexpress LLC Biotin-PEG11-SH | 1650579-23-9 | 98.0% | C34H65N3O13S2 | 10MG
BIOTIN-PEG11-SH is a thiol-reactive biotinylation reagent featuring an 11-unit polyethylene glycol spacer and a terminal thiol (-SH). Provided as a solid with typical purity of 98%, it enables efficient biotin labeling of proteins and other biomolecules via thiol chemistry while improving solubility and reducing steric hindrance.
- Enables biotin labeling via thiol-reactive chemistry.
- Reduces steric hindrance with an 11-unit PEG spacer.
- Improves aqueous solubility of labeled biomolecules.
- Suitable for protein conjugation and affinity capture workflows.
- Provided as a stable solid with high purity for consistent results.
Medchemexpress LLC Diketone-PEG4-biotin | 2353409-85-3 | 95.0% | C33H50N4O9S | 10MG
Diketone-PEG4-Biotin is a PEG-based PROTAC linker bearing a biotin affinity tag for use in chemical biology and targeted protein degradation research. It provides a flexible, water-soluble spacer to enable conjugation and affinity capture in the synthesis of bifunctional molecules and assay workflows.
- Peg-based linker with biotin for affinity capture.
- Compatible with PROTAC synthesis and bifunctional conjugates.
- Provides a flexible spacer to reduce steric hindrance.
- Facilitates pull-down assays and target engagement studies.
- Supplied with specified purity for research applications.
- Available in small research pack sizes for method development.
Medchemexpress LLC DBCO-PEG4-triethoxysilane | 2353410-02-1 | MFCD31811544 | 95.0% | C39H57N3O10Si | 10MG
DBCO-PEG4-triethoxysilane is a DBCO-functionalized PEG4 linker with a triethoxysilane end group, formulated for copper-free click chemistry and silane-based surface coupling. It is supplied as a colorless to light yellow liquid with good solubility in DMSO and is commonly provided at ~95% purity.
- Provides a dibenzocyclooctyne (DBCO) group for copper-free click reactions.
- Includes a PEG4 spacer to improve solubility and reduce steric hindrance.
- Features a triethoxysilane moiety for covalent attachment to silica and glass surfaces.
- Liquid form enables straightforward solution-phase handling and surface functionalization.
- Soluble in common organic solvents such as DMSO, facilitating formulation and reactions.
Medchemexpress LLC Hs-peg6-ch2ch2-boc | 1818294-40-4 | MFCD26127815 | 95.0% | 426.57 g/mol | C19H38O8S | 5 MG
HS-PEG6-CH2CH2-Boc is a PEG-based linker bearing a thiol terminus and a Boc-protected terminus, designed for use in the synthesis of PROTACs and other bifunctional molecules. It provides a flexible, hydrophilic spacer useful for connecting ligands while maintaining solubility and synthetic handle orthogonality.
- Suitable for use in PROTAC and bifunctional molecule synthesis.
- Thiol terminus enables selective conjugation to thiol-reactive partners.
- PEG6 spacer provides flexibility and improved aqueous solubility.
- Boc-protected terminus allows orthogonal protection and selective deprotection.
- Molecular formula C19H38O8S; molecular weight 426.57 g/mol.
Medchemexpress LLC DSPE-PEG-biotin | 98.4% | 3,400 (average) | 10 MG
DSPE-PEG-Biotin is an amphiphilic phospholipid-polyethylene glycol conjugate functionalized with biotin (average molecular weight 3,400). Supplied as a white solid, it is used to introduce biotin groups into lipid membranes and liposomal formulations for labeling, affinity capture, and targeted delivery studies in biochemical and drug-delivery research. Powder storage and solvent storage recommendations are provided by the manufacturer.
Medchemexpress LLC Pomalidomide-PEG4-C-COOH | 2097938-44-6 | MFCD31540390 | 99.2% | 507.49 g·mol⁻¹ | C23H29N3O10 | 10 MG
Pomalidomide-PEG4-C-COOH is an E3 ligase ligand-linker conjugate that combines a pomalidomide-derived cereblon ligand with a four-unit polyethylene glycol (PEG4) spacer terminating in a carboxylic acid. It is intended for use in targeted protein degradation research and PROTAC design, providing a conjugation handle and improved linker flexibility and solubility.
- Contains pomalidomide-based cereblon ligand.
- Four-unit PEG linker provides flexibility and solubility.
- Terminal carboxylic acid enables conjugation to target ligands.
- Designed for PROTAC design and chemical biology applications.
- High purity (99.19% by LCMS).
- Molecular weight 507.49 g·mol⁻¹; formula C23H29N3O10.
- Available in small research quantities suitable for assay development.